mcline
Jun 23, 2026
Feeling frustrated
I'm curious if anyone else is in a similar situation.
I'm 48 and about 5 weeks into tirzepatide. I've struggled with weight gain for years and was hoping this would help not just with weight, but also inflammation and overall feeling better.
So far, my appetite is lower at times, but I'm also dealing with bloating and constipation and honestly don't feel much different overall. I have brain fog, trouble concentrating, and just don't feel like myself anymore. I'm also wondering if perimenopause is playing a role.
For those of you in your late 40s, did tirzepatide eventually help you feel better? Did you notice improvements after 8–12 weeks? Or did you find that HRT or something else made a bigger difference?
Just looking for honest experiences.
